Clinical Update from MedScape

Heavy Beer Drinkers With ADH1 Gene Variant May Have Increased Risk Of Gastric Cancer.
Medscape (4/15, Nelson) reported that a “genetic variant might predispose heavy beer drinkers to a higher risk for gastric cancer,” according to findings presented at the American Association for Cancer Research meeting. The researchers found that drinking “30 g of pure ethanol/alcohol or more a day derived from beer was associated with a 75% increased risk for gastric cancer.” Notably, when they looked at interactions between the alcohol dehydrogenase gene cluster (ADH1) “locus SNPs and baseline alcohol consumption, the authors noted a statistically significant interaction between rs1230025 and beer consumption.” The presence of “SNP rs230025 was associated with a 30% increased risk for gastric cancer.”