Patient Instructions for Undergoing Capsule Endoscopy:                                                                                                                         

Your physician has determined that as part of your medical evaluation you should undergo an examination known as Capsule Endoscopy. This procedure involves ingesting a small (the
size of a large vitamin pill) Given® Imaging M2A® Capsule which will pass naturally through
your digestive system while taking pictures of the intestine. The images are transmitted to the SensorArray™ which is placed on your abdomen.

The SensorArray is attached to a walkman-like Given® DataRecorder™ which saves all the images. It is located in the RecorderBelt™, which is worn around your waist. After 8 hours, you will remove the RecorderBelt and return it to your physician for processing. The M2A Capsule is disposable and will be excreted naturally in your bowel movement. In the rare case that it will not be excreted naturally, it will need to be removed endoscopically or surgically. In order for your physician to get the most accurate information from this examination, you will need to follow the instructions below:

1. After lunch on the day before the Capsule Endoscopy examination, start the
   liquid diet your physician perscribed. From 10 p.m. the evening before Capsule
   Endoscopy, do not eat or drink except for necessary medication with a sip of water.
2. Do not take any medication beginning 2 hours before undergoing Capsule Endoscopy.
3. Abstain from smoking 24 hours prior to undergoing Capsule Endoscopy.
4. Male patients should shave their abdomen 6 inches (15 centimeters) above and below the navel on the day of the exmination. If it is difficult for you to shave your abdomen, please contact your physician's office to arrange to have this done in advance.

Day of Capsule Endoscopy:

1. Arrive at your physician's office at the prescribed time for your Capsule
   Endoscopy dressed in loose fitting, two-piece clothing.
2. At your physician's office, you will have a pre-procedure interview. During
   this interview you should be informed that Capsule Endoscopy is associated
   with a small chance of intestinal obstruction. You will be checked-in and
   asked to give your informed consent.
3. The SensorArray will be applied to your abdomen with adhesive pads and
   will be connected to the DataRecorder which you will wear in a belt around
   your waist. After that you will be instructed to ingest the M2A Capsule.

After Ingesting the M2A® Capsule:

1. After ingesting the M2A Capsule, do not eat or drink for at least 2 hours. After 4
   hours you may have a light snack. After the examination is completed, you may
   return to your normal diet. The above instructions related to eating apply, unless
   your physician specifies otherwise. Contact your physician immediately if you
   suffer from any abdominal pain, nausea or vomiting during Capsule Endoscopy.
2. After ingesting the M2A Capsule and until it is excreted, you should not be near
   any source of powerful electromagnetic fields such as one created near an
   MRI device or amateur (ham) radio.
3. Occasionally, some images may be lost due to radio interference (e.g. from amateur radio transmitter, MRI, etc.). On rare occasions this may result in the need to repeat the Capsule Endoscopy exmination. In this case, the physician will advise you to stay within the premises of the clinic during the Capsule Endoscopy to prevent this problem from recurring.
4. Capsule Endoscopy lasts approximately 8 hours and is considered complete according to your physician's instructions. Do not disconnect the equipment or remove the belt at any time during this period. Since the DataRecorder is actually a small computer, it should be treated with utmost care and protection. Avoid sudden movement and banging of the DataRecorder.
5. During Capsule Endoscopy, you will need to verify every 15 minutes that the small light on top of the DataRecorder is blinking twice per second. If, for some reason it stops blinking at this rate, record the time and contact your physician. You should also record the time and nature of any event such as eating, drinking, your activity and unusual sensations. Return the Event Form with these notes to your physician at the time you return the equipment.
6. Avoid any strenuous physical activity especially if it involves sweating and do not
   bend over or stoop during Capsule Endoscopy.

After Completing Capsule Endoscopy:

1. You will be instructed by your physician on how to return the equipment at the end of Capsule Endoscopy. If you were instructed to remove the equipment by yourself, do the following: (a) Disconnect the SensorArray from the DataRecorder; (b) Take off the RecorderBelt (with the DataRecorder and Battery Pack); (c) Disconnect the Battery Pack from the DataRecorder (d) Place DataRecorder and Battery Pack in a safe place. To remove the SensorArray from your abdomen, do not pull the leads of the SensorArray! Peel off each adhesive sleeve starting with the non-adhesive tab without removing the sensor from the adhesive sleeve. Place the SensorArray with the rest of the equipment.
2. The DataRecorder stores the images of your examination. Handle the DataRecorder, RecorderBelt, SensorArray and Battery Pack carefully. Do not expose them to shock, vibration or direct sunlight, which may result in loss of information. Return all of the equipment to your physician's office as soon as possible.
3. If you did not positively verify the excretion of the M2A Capsule from your body, and you develop unexplained post procedure nausea, abdominal pain or vomiting, contact your physician for evaluation and possible abdominal X-ray examination.
4. Undergoing an MRI while the capsule is inside your body may result in serious damage to your intestinal tract or abdominal cavity. If you did not positively verify the excretion of the M2A ® Capsule from your body, you should contact your physician for evaluation and possible abdominal X-ray before undergoing an MRI.